Like P. ginseng, P. quinquefolius and P. vietnamensis, notoginseng contains dammarane-type ginsenosides as the major constituents. Dammarane type ginsenosides includes 2 classifications: the 20(S)-protopanaxadiol (ppd) and 20(S)-protopanaxatriol (ppt) classifications. P. notoginseng contains high levels of Rb1, Rd (ppd classification) and Rg1 (ppt classification)ginsenosides. Rb1, Rd and Rg1 content of P. notoginseng is found to be higher than that of P. ginseng and P. quinquefolius in one study.[3]
Pharmacokinetics
When taken orally, ppd-type ginsenosides are mostly metabolized by intestinal bacteria to ppd monoglucoside, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (M1). [4] In humans, M1 is detected in plasma from 7 hours after the intake of ppd-type ginsenosides and in urine from 12 hours after the intake. These findings indicate that M1 is the final metabolite of ppd-type ginsenosides. [5]
M1 is referred to in some articles as IH-901 [6] , and in others as compound-K. [5]
| Zone | Weight | Delivery Fee (RM) |
|---|---|---|
| West Malaysia | First 2.00 kg | 7.00 |
| Extra 1.00 kg | 1.00 | |
| East Malaysia | First 0.50 kg | 8.00 |
| Extra 0.50 kg | 6.00 |
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